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Tryptase on NOVEOS

Updated: Jun 11, 2023

Analytical and Clinical Performance of a Novel Chemiluminescent Microparticle Immunoassay for Detection of Tryptase.


Updated: June 23

EAACI 2023, Hamburg. Title: Analytical and Clinical Performance of a Novel Chemiluminescent Microparticle Immunoassay for Detection of Tryptase. R. Y. Tao, B. Braddock, A. Cruz-Campos, J. Sun, J. Garibay-Grande, E. Laderman

During an anaphylactic reaction or other reaction leading to clinical symptoms caused by mast cell degranulation, serum total tryptase concentrations usually increase substantially above baseline. Chronic mast cell activation is more difficult to diagnose because in some of these patients the tryptase levels are constantly elevated and may point to an occult form of mastocytosis. The most widely used approach to determine tryptase levels is by immunoassay. Here we introduce a novel, high throughput automated platform that utilizes magnetic microparticles in combination with fluorescence and chemiluminescence signals to quantify tryptase present in human serum. We demonstrate the analytical and clinical performance of the new chemiluminescent microparticle immunoassay for detection of total tryptase levels in this study.


CONCLUSION

The tryptase assay on the chemiluminescent microparticle immunoassay analyzer exhibited strong analytical and clinical performance for the determination of tryptase level in human serum samples.

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