Cross-Reactive Carbohydrate Determinants
IgE tests using a cellulose-solid phase can contain varying amounts of CCDs sufficient
to cause false-positive test results. (1)
CCD-FREE PEANUT COMPONENTS
ImmunoCAP Solid-phase
CCD False Positives Results
Despite using CCD-Free
Allergen Components
CCD-Free Peanut Components
Figure 1: All samples were tested using CCD-free peanut components and nineteen of the ImmunoCAP positive samples exhibited a change in reactivity in the presence of a CCD inhibitor due to reactivity to the ImmunoCAP solid phase rather than any interaction with the proteins themselves, thereby creating false positive results (2).
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Hemmer W, Altmann F, Holzweber F, et al. ImmunoCAP cellulose displays cross-reactive carbohydrate determinant (CCD) epitopes and can cause false-positive test results in patients with high anti-CCD IgE antibody levels. J Allergy Clin Immunol. 2018 Jan;141(1):372-381. DOI: 10.1016/j.jaci.2017.04.028.
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Data on File. NOVEOS™ (HYCOR); ImmunoCAP (Thermo Fisher Scientific);
Figure 1:
The New Standard
in allergy testing,
solving shortcomings
in current technologies.
