Noveos Types of assays
Test | Noveos | Noveos flex |
|---|---|---|
IgG RUO | Available Soon. Research Use Only. Not for Use in Diagnostic Procedures. | Available Soon. Research Use Only. Not for Use in Diagnostic Procedures. |
IgG4 RUO | Available Soon. Research Use Only. Not for Use in Diagnostic Procedures. | Available Soon. Research Use Only. Not for Use in Diagnostic Procedures. |
ECP RUO | ✅ | ✅ |
Tryptase RUO | ✅ | ✅ |
Components | ✅ | ✅ |
Total IgE | ✅ | ✅ |
Specific IgE | ✅ | ✅ |
Specific IgE:
Testing for Specific IgE measures hypersensitivity of immunoglobulin E (IgE) antibodies in the blood to substances that generate allergic response. Unlike total IgE testing, which measures the overall amount of IgE in the blood, specific IgE testing focuses on identifying antibodies associated with specific allergenic triggers, such as pollens, pet danders, molds, foods, and insect venoms.
Total IgE:
Total IgE refers to the total amount of immunoglobulin E (IgE) antibodies present in the blood. IgE is a type of antibody produced by the immune system in response to allergens, which are substances that can trigger allergic reactions, such as pollen, pet dander, food, and insect stings.
Tryptase RUO:
Tryptase testing measures the levels of tryptase, an enzyme released by mast cells, in the blood to help diagnose and monitor mast cell-related disorders. It is primarily used to identify systemic mastocytosis, assess anaphylactic reactions, and differentiate between allergic and non-allergic conditions.
ECP RUO:
In allergy testing and clinical settings, elevated Eosinophil cationic protein (ECP) levels indicate proliferation of eosinophils, a common white blood cell linked to conditions like asthma, allergic rhinitis, and certain skin disorders. Higher ECP levels may suggest increased inflammation and heightened allergic activity.
IgG4:
Unlike measuring the presence of specific IgE, which is linked to immediate hypersensitivity reactions, IgG4 is thought to play a protective role, potentially reducing allergic responses and contributing to desensitization in therapies such as immunotherapy. Measuring levels of IgG4 after sublingual immunotherapy (SLIT) or subcutaneous immunotherapy (SCIT) allows physicians to monitor patients progression toward tolerance for the given allergenic trigger.
IgG:
IgG testing for lung diseases, such as hypersensitivity pneumonitis, is clinically relevant, as it helps identify immune reactivity to environmental allergens like molds and bird proteins. In these cases, elevated IgG levels suggest chronic exposure and potential lung inflammation, aiding in the diagnosis and management of respiratory conditions.
Component Resolved Diagnostics (CRD):
Component testing is an advanced laboratory technique that identifies specific proteins (components) within allergen extracts responsible for triggering allergic reactions. By analyzing individual allergenic proteins rather than whole extracts, CRD provides a more precise and detailed understanding of a patient’s allergy profile. This method enhances diagnostic accuracy, helps differentiate between primary sensitization and cross-reactivity, and aids in determining the severity of allergic responses compared to traditional testing approaches.